Research Project Details

Improvement of Solubility of Poorly Aqueous Soluble Antifungal Drug by Using Different Techniques of Solid Dispersions.

Project ID: WUB/2022/P1/024

Project Duration: 2022 - 2023

Project Leader: Khurshid Jahan (Department of Pharmacy)

Project Members: Rahima Akter

For oral drug delivery system, enhancing drug solubility consequently its oral bioavailability is very challenging feature in drug developing system.  Bioavailability indicates the concentration of drug available in the systemic circulation and then available in the site of action. The inadequate solubility and dissolution rate in the aqueous gastrointestinal fluids cause inadequate bioavailability.  Poor bioavailability also lead to poor absorption, permeability then interactions with other drugs, increasing development cost, time etc. The Biopharmaceutics Classification System (BCS) is a guide provided by the U.S. Food and Drug Administration that prognosticate the intestinal drug absorption. Hence for class II (low solubility and high permeability) substances the bioavailability may be increased by using some techniques and water soluble polymers. My selected drug belongs to this group and aim is to enhance their solubility by modifying their characteristics with the help of some hydrophilic polymers. Solid dispersions (SDs) a useful pharmaceutical technique that may increase the dissolution, absorption, and therapeutic efficacy of drugs in dosage forms. Moreover about 85% of the most sold drugs in the markets are orally administered and several factors can make delay absorption when drugs are taken by this route. My chosen techniques based on certain aspects aim to increase the solubility of selected drug by using different techniques of SDs.